We’ve officially reached Week 10 of the 2025 fantasy football season, and every lineup choice matters as playoff races heat up. With bye weeks, injuries, and shifting usage across the league, managers need clarity more than ever before setting lineups.
Below are my Week 10 fantasy football rankings for QB, TE, WR, andRB, along with four must start players who have prime matchups and strong recent usage trends. Whether you're chasing upside or locking in safe floor plays, these rankings will help guide your lineup decisions this week.
Week 10 Quarterback Rankings
Tier 1
1. Josh Allen @ MIA
2. Lamar Jackson @ MIN
Tier 2
3. Justin Herbert vs PIT
4. Drake Maye @ TB
5. Jalen Hurts @ GB
6. Bo Nix vs LV
7. Jaxson Dart @ CHI
Tier 3
8. Caleb Williams vs NYG
9. Baker Mayfield vs NE
10. Jared Goff @ WAS
11. Daniel Jones vs ATL
12. Matthew Stafford @ SF
13. J.J. McCarthy vs BAL
Tier 4
14. Jordan Love vs PHI
15. Sam Darnold vs ARI
16. Mac Jones vs LAR
17. C.J. Stroud vs JAC
18. Justin Fields vs CLE
Tier 5
19. Aaron Rodgers @ LAC
20. Marcus Mariota vs DET
21. Tua Tagovailoa vs BUF
22. Bryce Young vs NO
23. Trevor Lawrence @ HOU
24. Michael Penix Jr. @ IND
Must Start: Quarterback
J.J. McCarthy vs BAL
J.J. McCarthy faces a bottom defense in the Ravens this week and after having a solid game returning from injury, I believe he will feast this game. McCarthy looked more comfortable against the Lions, and I think he will only do better against the Ravens.
Week 10 Tight End Rankings
Tier 1
1. Brock Bowers @ DEN
2. Trey McBride @ SEA
Tier 2
3. Tyler Warren vs ATL
4. Oronde Gadsden II vs PIT
5. Sam LaPorta @ WAS
6. George Kittle vs LAR
Tier 3
7. Dallas Goedert @ GB
8. Dalton Kincaid @ MIA
9. Colston Loveland vs NYG
10. Kyle Pitts Sr. @ IND
11. Harold Fannin Jr. @ NYJ
12. Zach Ertz vs DET
Tier 4
13. Theo Johnson @ CHI
14. Hunter Henry @ TB
15. Mark Andrews @ MIN
16. Evan Engram vs LV
17. Cade Otton vs NE
18. Juwan Johnson @ CAR
Tier 5
19. T.J. Hockenson vs BAL
20. David Njoku @ NYJ
21. Dalton Schultz vs JAC
22. AJ Barner vs ARI
23. Luke Musgrave vs PHI
24. Jonnu Smith @ LAC
Must Start: Tight End
Theo Johnson @ CHI
Theo Johnson faces a bottom 10 defense against the tight end position in the Bears. With all the injuries and a great matchup this is a perfect spot for Johnson to thrive and find the endzone. Last week he caught a touchdown and that was against a good 49ers defense against the tight ends so don’t be surprised when Johnson has a big game.
Week 10 Wide Receiver Rankings
Tier 1
1. Puka Nucua @ SF
2. Jaxon Smith-Njigba vs ARI
3. Amon-Ra St. Brown @ WAS
4. Drake London @ IND
Tier 2
5. Justin Jefferson @ DET
6. Davante Adams @ SF
7. Emeka Egbuka vs NE
8. Nico Collins vs JAC
9. Rome Odunze vs NYG
Tier 3
10. Ladd McConkey vs PIT
11. Jaylen Waddle vs BUF
12. Garrett Wilson vs CLE
13. Courtland Sutton vs LV
14. Zay Flowers @ MIN
15. DeVonta Smith @ GB
16. A.J. Brown @ GB
Tier 4
17. DJ Moore vs NYG
18. Deebo Samuel Sr. vs DET
19. Michael Pittman Jr. vs ATL
20. Stefon Diggs @ TB
21. Jordan Addison vs BAL
22. Keenan Allen vs PIT
23. Marvin Harrison Jr. @ SEA
Tier 5
24. Quentin Johnston vs PIT
25. Chris Olave @ CAR
26. DK Metcalf @ LAC
27. Tetairoa McMillan vs NO
28. Wan’Dale Robinson @ CHI
29. Khalil Shakir @ MIA
Tier 6
30. Juan Jennings vs LAR
31. Romeo Doubs vs PHI
32. Jameson Williams @ WAS
33. Alec Pierce vs ATL
34. Rashid Shaheed @ CAR
35. Christian Watson vs PHI
36. Troy Franklin vs LV
Must Start: Wide Receiver
DJ Moore vs NYG
DJ Moore was more involved in Ben Johnson’s offense last week against the Bengals. This week Moorefaces a bottom defense in the Giants where I believe he will be involved again and has high touchdown upside this week and should be in your lineup.
Week 10 Running Back Rankings
Tier 1
1. Christian McCaffrey vs LAR
2. Jonathon Taylor vs ATL
3. De’Von Achane vs BUF
4. Bijan Robinson @ IND
Tier 2
5. James Cook III @ MIA
6. Jahmyr Gibbs @ WAS
7. Saquon Barkley @ GB
8. Josh Jacobs vs PHI
9. Derrick Henry @ MIN
Tier 3
10. Kyren Williams @ SF
11. Ashton Jeanty @ DEN
12. Bucky Irving vs NE
13. J.K. Dobbins vs LV
14. Rico Dowdle vs NO
15. Jaylen Warren @ LAC
16. Breece Hall vs CLE
Tier 4
17. D’Andre Swift vs NYG
18. Quinshon Judkins @ NYJ
19. Kimani Vidal vs PIT
20. RJ Harvey vs LV
21. Tyrone Tracy Jr. @ CHI
22. TreVeyon Henderson @ TB
23. Kyle Monangai vs NYG
24. David Montgomery @ WAS
Tier 5
25. Travis Etienne Jr. @ HOU
26. Trey Benson @ SEA
27. Kenneth Walker III vs ARI
28. Aaron Jones Sr. vs BAL
29. Zach Charbonnet vs ARI
30. Alvin Kamara @ CAR
31. Jordan Mason vs BAL
Tier 6
32. Jacory Croskey-Merritt vs DET
33. Devin Singletary @ CHI
34. Nick Chubb vs JAC
35. Bhayshul Tuten @ HOU
36. Rachaad White vs NE
Must Start: Running Back
Rico Dowdle vs NO
Rico Dowdle has been an elite running back ever since Chuba Hubbard got injured. Dowdle completely took over the running back role in Carolina as Dowdle had 130 rush yards on 25 carries with 2 rushing touchdowns and 2 receptions for 11 yards. I am no longer worried about the split and against a bottom half run defense in the Saints. I believe Dowdle will have another big game and is a must start.
Conclusion
Week 10 brings pivotal matchups and plenty of opportunities for fantasy production, and leaning on the right players could be the difference between securing a playoff push or falling behind. J.J. McCarthy, Theo Johnson, DJ Moore, and Rico Dowdle all carry strong upside with favorable matchups and rising roles in their offenses, making them standout players this week.
With stars producing at elite levels and emerging players taking on bigger workloads, make sure you're staying flexible and playing the matchups. Lock in your best options, stay active on the waiver wire, and get ready to keep climbing the standings it’s winning season.