The 2025 Fantasy Football season keeps heating up as we head into Week 6, and with injuries, bye weeks, and breakout players shaking up lineups, getting your lineup decisions right is more important than ever.
Below is the complete quarterback, running back, wide receiver, and tight end rankings, along with this week’s must start players who can give your team a much needed edge.
Week 6 Quarterback Rankings
Tier 1
1. Josh Allen @ ATL
2. Jalen Hurts @ NYG
3. Jayden Daniels vs CHI
Tier 2
4. Justin Herbert @ MIA
5. Patrick Mahomes II vs DET
6. Justin Fields vs DAL
Tier 3
7. Drake Maye @ NO
8. Jordan Love vs CIN
9. Caleb Williams @ WAS
10. Baker Mayfield vs SF
11. Daniel Jones vs ARI
12. Dak Prescott @ CAR
Tier 4
13. Justin Fields vs DEN
14. Bo Nix @ NYJ
15. Matthew Stafford @ BAL
16. Jared Goff @ KC
17. Kyler Murray @ IND
18. Jaxson Dart vs PHI
Tier 5
19. Sam Darnold @ JAC
20. Bryce Young vs DAL
21. Geno Smith vs TEN
22. Trevor Lawrence vs SEA
23. Tua Tagovailoa vs LAC
Must Start: Quarterback
Bo Nix @ NYJ
The Jets’ defense has been inconsistent, and Nix has quietly delivered solid fantasy outings with his dual threat ability. Expect him to post QB1 numbers in what could be a pass heavy game script. The game script allows him to have a safe floor and a high ceiling where I feel condiment he will produce 20 plus points this week.
Week 6 Tight End Rankings
Tier 1
1. Trey McBride @ IND
2. Jake Ferguson @ CAR
3. Tyler Warren vs ARI
Tier 2
4. Tucker Kraft vs CIN
5. Sam LaPorta @ KC
6. Dalton Kincaid @ ATL
7. Hunter Henry @ NO
8. Darren Waller vs LAC
Tier 3
9. Travis Kelce vs DET
10. Dallas Goedert @ NYG
11. Zach Ertz vs CHI
12. Kyle Pitts Sr. vs BUF
13. Brenton Strange vs SEA
14. Juwan Johnson vs NE
Tier 4
15. Mason Taylor vs DEN
16. David Njoku @ PIT
17. Theo Johnson vs PHI
18. Jake Tonges @ TB
19. Harold Fannin Jr. @ PIT
Tier 5
20. Mark Andrews vs LAR
21. Evan Engram @ NYJ
22. AJ Barner @ JAC
23. Jonnu Smith vs CLE
24. Chig Okonkwo @ LV
Must Start: Tight End
Juwan Johnson vs NE
Johnson remains one of the Saints’ most reliable red zone weapons, and with New England struggling to contain tight ends, he’s a solid streaming option and fringe TE1 play this week. He has had a rough last two weeks, but I believe he will bounce back and post good numbers this week.
Week 6 Wide Receiver Rankings
Tier 1
1. Puka Nucua @ BAL
2. Amon-Ra St. Brown @ KC
3. Jaxon Smith-Njigba @ JAC
Tier 2
4. Ja’Marr Chase @ GB
5. Rome Odunze @ WAS
6. Emeka Egbuka vs SF
7. Garrett Wilson vs DEN
8. Drake London vs BUF
Tier 3
9. Deebo Samuel Sr. vs CHI
10. Davante Adams @ BAL
11. George Pickens @ CAR
12. Jaylen Waddle vs LAC
13. Courtland Sutton @ NYJ
14. Tetairoa McMillan vs DAL
15. Quentin Johnston @ MIA
16. Michael Pittman Jr. vs ARI
17. Ladd McConkey @ MIA
18. Xavier Worthy vs DET
19. Keenan Allen @ MIA
Tier 4
20. A.J. Brown @ NYG
21. Marvin Harrison Jr. @ IND
22. Brian Thomas Jr. vs SEA
23. Jakobi Meyers vs TEN
24. Zay Flowers vs LAR
25. DK Metcalf vs CLE
Tier 5
26. Stefon Diggs @ NO
27. DeVonta Smith @ NYG
28. Chris Olave vs NE
29. DJ Moore @ WAS
30. Tee Higgins @ GB
Tier 6
31. Matthew Golden vs CIN
32. Calvin Ridley @ LV
33. Khalil Shakir @ ATL
34. Jameson Williams @ KC
35. Romeo Doubs vs CIN
36. Wan’Dale Robinson vs PHI
Must Start: Wide Receiver
A.J. Brown @ NYG
Brown has been more than disappointing this year as he has only had one good week this year. However, he plays a bottom Giants defense where I believe Jalen Hurts will sling the ball around and the Eagles are looking for a dominate win after falling to the Broncos having a big lead. Brown will feast this game and will hopefully set his momentum going forward.
Week 6 Running Back Rankings
Tier 1
1. Christian McCaffrey @ TB
2. Jonathon Taylor vs ARI
3. Bijan Robinson vs BUF
4. Saquon Barkley @ NYG
Tier 2
5. Jahmyr Gibbs @ KC
6. Josh Jacobs vs CIN
7. De’Von Achane vs LAC
8. James Cook III @ ATL
9. Javonte Williams @ CAR
10. Breece Hall vs DEN
Tier 3
11. Kyren Williams @ BAL
12. Ashton Jeanty vs TEN
13. Quinshon Judkins @ PIT
14. Rico Dowdle vs DAL
15. Cam Skattebo vs PHI
16. Derrick Henry vs LAR
17. Travis Etienne Jr. vs SEA
Tier 4
18. J.K. Dobbins @ NYJ
19. Jacory Croskey-Merritt vs CHI
20. Kenneth Walker III @ JAC
21. Rachaad White vs SF
22. David Montgomery @ KC
Tier 5
23. Alvin Kamara vs NE
24. Michael Carter @ IND
25. Jaylen Warren vs CLE
26. D’Andre Swift @ WAS
27. Chase Brown @ GB
28. Tony Pollard @ LV
29. TreVeyon Henderson @ NO
Tier 6
30. Rhamondre Stevenson @ NO
31. Kenneth Gainwell vs CLE
32. Zach Charbonnet @ JAC
33. RJ Harvey @ NYJ
34. Bhayshul Tuten vs SEA
35. Isiah Pacheco vs DET
Must Start: Running Back
Rico Dowdle vs DAL
Dowdle is facing a bottom run defense in the Cowboys, and he is coming of 206 yards on 23 attempts and a touchdown with 3 receptions for 28 yards. Depending on Chuba Hubbard’s status, Dowdle will feast and is set for another big game against his former team in the Cowboys.
Verdict
Week 6 features several juicy matchups across the board, making lineup decisions tougher than usual. Bo Nix looks like a safe play against the Jets’ shaky secondary, while Juwan Johnson has touchdown potential against New England. A.J. Brown should dominate New York’s secondary with elite volume, and Rico Dowdle could surprise as a productive flex against a soft run defense.
With injuries piling up and bye weeks in play, these must starts can give your roster the edge it needs heading into the heart of the 2025 Fantasy Football season.